| Day | Date | Opponent | Location | TV | |
| Sat | 09/04/2004 | Throwback Game
Iowa vs. Kent State | Iowa City, IA (Varsity Club Day) | ESPN Plus | W, 39-7
Recap | Stats | Quotes | Notes | Photo Gallery | Gametracker |
| Sat | 09/11/2004 | Iowa State | Iowa City, IA (Hy-Vee Cy-Hawk Series) | ESPN Plus | W, 17-10
Recap | Stats | Quotes | Notes | Photo Gallery | Gametracker |
| Sat | 09/18/2004 | Arizona State | Tempe, AZ | ESPN Plus/Fox Sports Arizona | L, 44-7
Recap | Stats | Notes | Photo Gallery | Gametracker |
| Sat | 09/25/2004 | Michigan | Ann Arbor, MI | ABC-TV (Regional) | L, 30-17
Recap | Final Stats | Notes | Photo Gallery | Gametracker |
| Sat | 10/02/2004 | Michigan State | Iowa City, IA (Homecoming) | ESPN Plus | W, 38-16
Recap | Stats | Notes | Photo Gallery | Gametracker |
| Sat | 10/16/2004 | Ohio State | Iowa City, IA | ABC-TV (Regional) | W, 33-7
Recap | Stats | Quotes | Notes | Photo Gallery | Gametracker |
| Sat | 10/23/2004 | Penn State | State College, PA | ESPN 2 | W, 6-4
Recap | Stats | Notes | Gametracker |
| Sat | 10/30/2004 | Illinois | Champaign, IL | ESPN Plus | W, 23-13
Recap | Final Stats | Notes | Photo Gallery | Gametracker |
| Sat | 11/06/2004 | Purdue | Iowa City, IA (Parents Weekend) | ESPN | W, 23-21
Recap | Stats | Quotes | Notes | Photo Gallery | Gametracker |
| Sat | 11/13/2004 | Minnesota | Minneapolis, MN | ESPN | W, 29-27
Recap | Stats | Notes | Photo Gallery | Gametracker |
| Sat | 11/20/2004 | Wisconsin | Iowa City, IA (Fan Appreciation Day) | ESPN | W, 30-7
Recap | Stats | Notes | Photo Gallery | Gametracker |
| Sat | 01/01/2005 | LSU | Orlando, FL (Capital One Bowl) | ABC | W, 30-25
Recap | Stats | Notes | Photo Gallery | Gametracker |
